Combined Usage of Trimetazidine With 3-Bromopyruvate May Lead to Cardiotoxicity by Activating Oxidative Stress and Apoptosis in Rats.

Zheng, Min; Zhan, Chengchuang; Bai, Nan; Bai, Juncai; Nie, Chaoqun; Chi, Jing; Ding, Xue; Liu, Jiaren; Yang, Wei

Zheng, Min; Zhan, Chengchuang; Bai, Nan; Bai, Juncai; Nie, Chaoqun; Chi, Jing; Ding, Xue; Liu, Jiaren; Yang, Wei.

Afiliação

Zheng M; Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; and.
Zhan C; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Bai N; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Bai J; Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; and.
Nie C; Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; and.
Chi J; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Ding X; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Liu J; Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; and.
Yang W; Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; and.

J Cardiovasc Pharmacol ; 78(6): 819-825, 2021 12 01.

Article em En | MEDLINE | ID: mdl-34524259

Assuntos

Apoptose/efeitos dos fármacos; Fármacos Cardiovasculares/toxicidade; Inibidores Enzimáticos/toxicidade; Cardiopatias/induzido quimicamente; Miócitos Cardíacos/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Piruvatos/toxicidade; Trimetazidina/toxicidade; Trifosfato de Adenosina/metabolismo; Animais; Cardiotoxicidade; Metabolismo Energético/efeitos dos fármacos; Cardiopatias/metabolismo; Cardiopatias/patologia; Cardiopatias/fisiopatologia; Masculino; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/patologia; Ratos Wistar; Transdução de Sinais; Função Ventricular Esquerda/efeitos dos fármacos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piruvatos / Trimetazidina / Fármacos Cardiovasculares / Apoptose / Estresse Oxidativo / Miócitos Cardíacos / Inibidores Enzimáticos / Cardiopatias Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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