Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.

Tang, Qiannan; Rigby, Rachel E; Young, George R; Hvidt, Astrid Korning; Davis, Tanja; Tan, Tiong Kit; Bridgeman, Anne; Townsend, Alain R; Kassiotis, George; Rehwinkel, Jan

Tang, Qiannan; Rigby, Rachel E; Young, George R; Hvidt, Astrid Korning; Davis, Tanja; Tan, Tiong Kit; Bridgeman, Anne; Townsend, Alain R; Kassiotis, George; Rehwinkel, Jan.

Afiliação

Tang Q; Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Rigby RE; Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Young GR; Bioinformatics and Biostatistics STP, The Francis Crick Institute, London, NW1 1AT, UK.
Hvidt AK; Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Davis T; Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Tan TK; Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Bridgeman A; Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Townsend AR; Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of O
Kassiotis G; Retroviral Immunology, The Francis Crick Institute, London, NW 1AT, UK; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, W2 1NY, UK.
Rehwinkel J; Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK. Electronic address: jan.rehwinkel@imm.ox.ac.uk.

Immunity ; 54(9): 1961-1975.e5, 2021 09 14.

Article em En | MEDLINE | ID: mdl-34525337

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/imunologia; Adenosina Desaminase/genética; Interferon Tipo I/imunologia; RNA de Cadeia Dupla/genética; Adenosina/genética; Adenosina/metabolismo; Animais; Doenças Autoimunes do Sistema Nervoso/genética; Doenças Autoimunes do Sistema Nervoso/imunologia; Inosina/genética; Inosina/metabolismo; Interferon Tipo I/genética; Camundongos; Mutação; Malformações do Sistema Nervoso/genética; Malformações do Sistema Nervoso/imunologia; Edição de RNA/genética; RNA de Cadeia Dupla/metabolismo

Palavras-chave

ADAR1; AicardiGoutières syndrome; MAVS; MDA5; RNA editing; Z-RNA; Zα domain; influenza A virus; interferon; neutrophil

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA de Cadeia Dupla / Interferon Tipo I / Adenosina Desaminase / Proteínas Adaptadoras de Transdução de Sinal Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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