Branched-chain amino acids regulate hyaluronan synthesis and PPARα expression in the skin.
Biosci Biotechnol Biochem
; 85(11): 2292-2294, 2021 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-34529047
We examined the effects of deletion of branched-chain α-keto acid dehydrogenase kinase (BDK), a key enzyme in branched-chain amino acid catabolism, on hyaluronan synthesis in mice. The skin levels of hyaluronan and the gene expression levels of hyaluronan synthase (Has)2, Has3, and peroxisome proliferator-activated receptor-α were significantly lower in the BDK-knockout group than in the wild-type group.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminoácidos de Cadeia Ramificada
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article