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Branched-chain amino acids regulate hyaluronan synthesis and PPARα expression in the skin.
Yamane, Takumi; Kitaura, Yasuyuki; Iwatsuki, Ken; Shimomura, Yoshiharu; Oishi, Yuichi.
Afiliação
  • Yamane T; Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya-ku, Tokyo, Japan.
  • Kitaura Y; Laboratory of Nutritional Biochemistry, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
  • Iwatsuki K; Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya-ku, Tokyo, Japan.
  • Shimomura Y; Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University, Aichi, Japan.
  • Oishi Y; Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya-ku, Tokyo, Japan.
Biosci Biotechnol Biochem ; 85(11): 2292-2294, 2021 Oct 21.
Article em En | MEDLINE | ID: mdl-34529047
We examined the effects of deletion of branched-chain α-keto acid dehydrogenase kinase (BDK), a key enzyme in branched-chain amino acid catabolism, on hyaluronan synthesis in mice. The skin levels of hyaluronan and the gene expression levels of hyaluronan synthase (Has)2, Has3, and peroxisome proliferator-activated receptor-α were significantly lower in the BDK-knockout group than in the wild-type group.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aminoácidos de Cadeia Ramificada Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aminoácidos de Cadeia Ramificada Idioma: En Ano de publicação: 2021 Tipo de documento: Article