The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.

Martin, Timothy D; Patel, Rupesh S; Cook, Danielle R; Choi, Mei Yuk; Patil, Ajinkya; Liang, Anthony C; Li, Mamie Z; Haigis, Kevin M; Elledge, Stephen J

Martin, Timothy D; Patel, Rupesh S; Cook, Danielle R; Choi, Mei Yuk; Patil, Ajinkya; Liang, Anthony C; Li, Mamie Z; Haigis, Kevin M; Elledge, Stephen J.

Afiliação

Martin TD; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Patel RS; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Cook DR; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Choi MY; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Patil A; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Liang AC; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Li MZ; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Haigis KM; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Elledge SJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Science ; 373(6561): 1327-1335, 2021 Sep 17.

Article em En | MEDLINE | ID: mdl-34529489

Assuntos

Carcinogênese; Inativação Gênica; Genes Supressores de Tumor; Evasão da Resposta Imune; Neoplasias Experimentais/genética; Neoplasias Experimentais/imunologia; Animais; Sistemas CRISPR-Cas; Linhagem Celular Tumoral; Quimiocina CCL2/metabolismo; Feminino; Subunidades alfa G12-G13 de Proteínas de Ligação ao GTP/genética; Subunidades alfa G12-G13 de Proteínas de Ligação ao GTP/metabolismo; Humanos; Evasão da Resposta Imune/genética; Neoplasias Mamárias Experimentais/genética; Neoplasias Mamárias Experimentais/imunologia; Neoplasias Mamárias Experimentais/patologia; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Camundongos SCID; Transplante de Neoplasias; Neoplasias Experimentais/patologia; Seleção Genética; Microambiente Tumoral

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genes Supressores de Tumor / Inativação Gênica / Evasão da Resposta Imune / Carcinogênese / Neoplasias Experimentais Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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