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Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa.
Ahuno, Samuel Terkper; Doebley, Anna-Lisa; Ahearn, Thomas U; Yarney, Joel; Titiloye, Nicholas; Hamel, Nancy; Adjei, Ernest; Clegg-Lamptey, Joe-Nat; Edusei, Lawrence; Awuah, Baffour; Song, Xiaoyu; Vanderpuye, Verna; Abubakar, Mustapha; Duggan, Maire; Stover, Daniel G; Nyarko, Kofi; Bartlett, John M S; Aitpillah, Francis; Ansong, Daniel; Gardner, Kevin L; Boateng, Felix Andy; Bowcock, Anne M; Caldas, Carlos; Foulkes, William D; Wiafe, Seth; Wiafe-Addai, Beatrice; Garcia-Closas, Montserrat; Kwarteng, Alexander; Ha, Gavin; Figueroa, Jonine D; Polak, Paz.
Afiliação
  • Ahuno ST; Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Doebley AL; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
  • Ahearn TU; Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA.
  • Yarney J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Titiloye N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
  • Hamel N; Korle Bu Teaching Hospital, Accra, Ghana.
  • Adjei E; Komfo Anokye Teaching Hospital, Kumasi, Ghana.
  • Clegg-Lamptey JN; Research Institute of the McGill University Health Centre, Montréal, QC, Canada.
  • Edusei L; Komfo Anokye Teaching Hospital, Kumasi, Ghana.
  • Awuah B; Korle Bu Teaching Hospital, Accra, Ghana.
  • Song X; University of Ghana, Accra, Ghana.
  • Vanderpuye V; Korle Bu Teaching Hospital, Accra, Ghana.
  • Abubakar M; Komfo Anokye Teaching Hospital, Kumasi, Ghana.
  • Duggan M; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
  • Stover DG; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
  • Nyarko K; Korle Bu Teaching Hospital, Accra, Ghana.
  • Bartlett JMS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
  • Aitpillah F; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.
  • Ansong D; Stefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, USA.
  • Gardner KL; Division of Medical Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Boateng FA; University of Ghana, Accra, Ghana.
  • Bowcock AM; Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Caldas C; Edinburgh Cancer Research Centre, Edinburgh, United Kingdom.
  • Foulkes WD; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
  • Wiafe S; Komfo Anokye Teaching Hospital, Kumasi, Ghana.
  • Wiafe-Addai B; School of Medicine & Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Garcia-Closas M; Department of Child Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Kwarteng A; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, USA.
  • Ha G; Komfo Anokye Teaching Hospital, Kumasi, Ghana.
  • Figueroa JD; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
  • Polak P; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
NPJ Precis Oncol ; 5(1): 83, 2021 Sep 17.
Article em En | MEDLINE | ID: mdl-34535742
ABSTRACT
Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article