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The QcrB Inhibitors TB47 and Telacebec Do Not Potentiate the Activity of Clofazimine in Mycobacterium abscessus.
Sorayah, Ria; Moraski, Garret C; Barkan, Daniel; Pethe, Kevin.
Afiliação
  • Sorayah R; NTU Institute for Health Technologies, Interdisciplinary Graduate Program, Nanyang Technological Universitygrid.59025.3b, Singapore.
  • Moraski GC; Lee Kong Chian School of Medicine, Nanyang Technological Universitygrid.59025.3b, Singapore.
  • Barkan D; Department of Chemistry and Biochemistry, Montana State Universitygrid.41891.35, Bozeman, Montana, USA.
  • Pethe K; Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Antimicrob Agents Chemother ; 65(12): e0096421, 2021 11 17.
Article em En | MEDLINE | ID: mdl-34543090
ABSTRACT
The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does not potentiate the activity of clofazimine.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium abscessus / Infecções por Mycobacterium não Tuberculosas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium abscessus / Infecções por Mycobacterium não Tuberculosas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article