What Is the Role of Steroids for Septic Shock in 2021?
Semin Respir Crit Care Med
; 42(5): 726-734, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34544190
ABSTRACT
Corticosteroids have been used for decades in the adjunctive treatment of severe infections in intensive care. The most frequent scenario in intensive care is in septic shock, where low doses of glucocorticoids appear to restore vascular responsiveness to norepinephrine. There is a strong body of evidence suggesting that hydrocortisone reduces time on vasopressor, and may modulate the immune response. In this review, we explore the current evidence supporting the use of corticosteroids in septic shock, its benefits, and potential harms. In addition to landmark clinical trials, we will also describe new frontiers for the use of corticosteroids in septic shock which should be explored in future studies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Choque Séptico
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article