Current views on N-glycolylneuraminic acid in therapeutic recombinant proteins.

Mastrangeli, Renato; Audino, Maria Concetta; Palinsky, Wolf; Broly, Hervé; Bierau, Horst

Mastrangeli, Renato; Audino, Maria Concetta; Palinsky, Wolf; Broly, Hervé; Bierau, Horst.

Afiliação

Mastrangeli R; Technology & Innovation, CMC Science & Intelligence, Merck Serono SpA (an affiliate of Merck KgaA, Darmstadt, Germany), Guidonia Montecelio (Rome), Italy.
Audino MC; Technology & Innovation, CMC Science & Intelligence, Merck Serono SpA (an affiliate of Merck KgaA, Darmstadt, Germany), Guidonia Montecelio (Rome), Italy.
Palinsky W; Biotech Development Programme, Merck Biopharma (an affiliate of Merck KgaA, Darmstadt, Germany), Aubonne, Switzerland.
Broly H; Biotech Process Sciences, Merck Serono S.A. (an affiliate of Merck KgaA, Darmstadt, Germany), Corsier-sur-Vevey, Switzerland.
Bierau H; Technology & Innovation, CMC Science & Intelligence, Merck Serono SpA (an affiliate of Merck KgaA, Darmstadt, Germany), Guidonia Montecelio (Rome), Italy. Electronic address: horst.bierau@merckgroup.com.

Trends Pharmacol Sci ; 42(11): 943-956, 2021 11.

Article em En | MEDLINE | ID: mdl-34544608

Assuntos

Anticorpos; Ácidos Neuramínicos; Humanos; Ácidos Neuramínicos/química; Proteínas Recombinantes/química; Proteínas Recombinantes/uso terapêutico

Palavras-chave

N-glycolylneuraminic acid; N-glycosylation; biotherapeutics; drug clearance; immunogenicity; recombinant proteins; sialic acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos / Ácidos Neuramínicos Tipo de estudo: Guideline / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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