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Proteopathic tau primes and activates interleukin-1ß via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.
Jiang, Shanya; Maphis, Nicole M; Binder, Jessica; Chisholm, Devon; Weston, Lea; Duran, Walter; Peterson, Crina; Zimmerman, Amber; Mandell, Michael A; Jett, Stephen D; Bigio, Eileen; Geula, Changiz; Mellios, Nikolaos; Weick, Jason P; Rosenberg, Gary A; Latz, Eicke; Heneka, Michael T; Bhaskar, Kiran.
Afiliação
  • Jiang S; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Maphis NM; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Binder J; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Chisholm D; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Weston L; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Duran W; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Peterson C; Department of Neurosciences, University of New Mexico, Albuquerque, NM 87131, USA.
  • Zimmerman A; Department of Neurosciences, University of New Mexico, Albuquerque, NM 87131, USA.
  • Mandell MA; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Jett SD; Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
  • Bigio E; Cognitive Neurology and Alzheimer's Disease Center (CNADC), Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Geula C; Cognitive Neurology and Alzheimer's Disease Center (CNADC), Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Mellios N; Department of Neurosciences, University of New Mexico, Albuquerque, NM 87131, USA.
  • Weick JP; Department of Neurosciences, University of New Mexico, Albuquerque, NM 87131, USA.
  • Rosenberg GA; Center for Memory and Aging, University of New Mexico, Albuquerque, NM 87131, USA.
  • Latz E; Institute of Innate Immunity, University of Bonn, Bonn 53127, Germany; Department of Medicine, University of Massachusetts, Worcester, MA 01605, USA.
  • Heneka MT; Institute of Innate Immunity, University of Bonn, Bonn 53127, Germany; Department of Medicine, University of Massachusetts, Worcester, MA 01605, USA; Department of Neurodegenerative Disease and Gerontopsychiatry, University of Bonn, Bonn 53127, Germany.
  • Bhaskar K; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA; Department of Neurology, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: kbhaskar@salud.unm.edu.
Cell Rep ; 36(12): 109720, 2021 09 21.
Article em En | MEDLINE | ID: mdl-34551296
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas tau / Tauopatias / Interleucina-1beta / Inflamassomos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas tau / Tauopatias / Interleucina-1beta / Inflamassomos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article