Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs).

Mohammed, Esraa Z; Mahmoud, Walaa R; George, Riham F; Hassan, Ghaneya S; Omar, Farghaly A; Georgey, Hanan H

Mohammed, Esraa Z; Mahmoud, Walaa R; George, Riham F; Hassan, Ghaneya S; Omar, Farghaly A; Georgey, Hanan H.

Afiliação

Mohammed EZ; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt. Electronic address: esraazakaria@o6u.edu.eg.
Mahmoud WR; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
George RF; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. Electronic address: riham.eskandar@pharma.cu.edu.eg.
Hassan GS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt; Pharmaceutical Chemistry Department, School of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
Omar FA; Medicinal Chemistry Department, Faculty of Pharmacy, Assuit University, 71526 Assuit, Egypt.
Georgey HH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, 11786 Cairo, Egypt.

Bioorg Chem ; 116: 105347, 2021 11.

Article em En | MEDLINE | ID: mdl-34555628

Assuntos

Antineoplásicos/farmacologia; Quinases Ciclina-Dependentes/antagonistas & inibidores; Inibidores de Proteínas Quinases/farmacologia; Pirazóis/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Quinases Ciclina-Dependentes/metabolismo; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Modelos Moleculares; Estrutura Molecular; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Pirazóis/síntese química; Pirazóis/química; Relação Estrutura-Atividade

Palavras-chave

Anti-proliferative; CDK inhibitors; Molecular docking; Pyrazole based derivatives

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Quinases Ciclina-Dependentes / Inibidores de Proteínas Quinases / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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