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Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease.
Al-Wahaibi, Lamya H; Mostafa, Ahmed; Mostafa, Yaser A; Abou-Ghadir, Ola F; Abdelazeem, Ahmed H; Gouda, Ahmed M; Kutkat, Omnia; Abo Shama, Noura M; Shehata, Mahmoud; Gomaa, Hesham A M; Abdelrahman, Mostafa H; Mohamed, Fatma A M; Gu, Xuyuan; Ali, Mohamed A; Trembleau, Laurent; Youssif, Bahaa G M.
Afiliação
  • Al-Wahaibi LH; Department of Chemistry, College of Sciences, Princess Nourah Bint Abdulrahman University, Saudi Arabia. Electronic address: lhalwahaibi@pnu.edu.sa.
  • Mostafa A; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.
  • Mostafa YA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
  • Abou-Ghadir OF; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
  • Abdelazeem AH; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Department of Pharmaceutical Sciences, College of Pharmacy, Riyadh Elm University, Riyadh 11681, Saudi Arabia.
  • Gouda AM; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
  • Kutkat O; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.
  • Abo Shama NM; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.
  • Shehata M; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.
  • Gomaa HAM; Pharmacology Department, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia.
  • Abdelrahman MH; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt; Chemistry Department, School of Natural and Computing Sciences, University of Aberdeen, Meston Building, Aberdeen AB24 3UE, United Kingdom.
  • Mohamed FAM; Clinical Laboratory Science Department, College of Applied Medical Sciences, Jouf University, Aljouf 72341, Saudi Arabia; Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21321, Egypt.
  • Gu X; Chemistry Department, School of Natural and Computing Sciences, University of Aberdeen, Meston Building, Aberdeen AB24 3UE, United Kingdom.
  • Ali MA; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.
  • Trembleau L; Chemistry Department, School of Natural and Computing Sciences, University of Aberdeen, Meston Building, Aberdeen AB24 3UE, United Kingdom. Electronic address: l.trembleau@abdn.ac.uk.
  • Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: bahaa.youssif@pharm.aun.edu.eg.
Bioorg Chem ; 116: 105363, 2021 11.
Article em En | MEDLINE | ID: mdl-34555629
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Oxazóis / Inibidores de Proteases / Compostos Macrocíclicos / Descoberta de Drogas / Proteases 3C de Coronavírus / SARS-CoV-2 Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Oxazóis / Inibidores de Proteases / Compostos Macrocíclicos / Descoberta de Drogas / Proteases 3C de Coronavírus / SARS-CoV-2 Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article