Interleukin-36&#945; inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8<sup>+</sup> T lymphocytes.

Wei, Xiuyu; Yao, Yongjie; Wang, Xiaoxi; Sun, Jiaxin; Zhao, Wenshan; Qiu, Lu; Zhai, Wenjie; Qi, Yuanming; Gao, Yanfeng; Wu, Yahong

Interleukin-36α inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8⁺ T lymphocytes.

Wei, Xiuyu; Yao, Yongjie; Wang, Xiaoxi; Sun, Jiaxin; Zhao, Wenshan; Qiu, Lu; Zhai, Wenjie; Qi, Yuanming; Gao, Yanfeng; Wu, Yahong.

Afiliação

Wei X; School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China.
Yao Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China.
Wang X; School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China.
Sun J; School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China.
Zhao W; School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China; Henan Key Laboratory of Bioactive Macromolecules, Zhengzhou University, Zhengzhou 450001, China.
Qiu L; School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China; Henan Key Laboratory of Bioactive Macromolecules, Zhengzhou University, Zhengzhou 450001, China.
Zhai W; School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China; Henan Key Laboratory of Bioactive Macromolecules, Zhengzhou University, Zhengzhou 450001, China.
Qi Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China; Henan Key Laboratory of Bioactive Macromolecules, Zhengzhou University, Zhengzhou 450001, China.
Gao Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China; International Joint Laboratory for Protein and Peptide Drugs of Henan Province, Zhengzhou University, Zhengzhou 450001, China. Electro
Wu Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China; International Joint Laboratory for Protein and Peptide Drugs of Henan Province, Zhengzhou University, Zhengzhou 450001, China. Electronic address: yahongwu@zzu.edu.cn.

Int Immunopharmacol ; 100: 108152, 2021 Nov.

Article em En | MEDLINE | ID: mdl-34555640

Assuntos

Adenocarcinoma; Linfócitos T CD8-Positivos; Movimento Celular; Neoplasias Colorretais; Interleucina-1; Neoplasias Pulmonares; Linfócitos do Interstício Tumoral; Animais; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Adenocarcinoma/genética; Adenocarcinoma/imunologia; Adenocarcinoma/metabolismo; Adenocarcinoma/secundário; Linfócitos T CD8-Positivos/imunologia; Linfócitos T CD8-Positivos/metabolismo; Proliferação de Células; Quimiocina CXCL10/metabolismo; Quimiocina CXCL11/metabolismo; Técnicas de Cocultura; Neoplasias Colorretais/genética; Neoplasias Colorretais/imunologia; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Bases de Dados Genéticas; Regulação Neoplásica da Expressão Gênica; Células HT29; Interleucina-1/genética; Interleucina-1/metabolismo; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/imunologia; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/secundário; Linfócitos do Interstício Tumoral/imunologia; Linfócitos do Interstício Tumoral/metabolismo; Camundongos Endogâmicos BALB C; Invasividade Neoplásica; Transdução de Sinais; Microambiente Tumoral

Palavras-chave

CD8(+) T lymphocytes; Colorectal cancer; Interleukin-36α; Metastasis; Tumor immunology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Adenocarcinoma / Movimento Celular / Linfócitos do Interstício Tumoral / Interleucina-1 / Linfócitos T CD8-Positivos / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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