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Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action.
Elkamhawy, Ahmed; Kim, Hyeon Jeong; Elsherbeny, Mohamed H; Paik, Sora; Park, Jong-Hyun; Gotina, Lizaveta; Abdellattif, Magda H; Gouda, Noha A; Cho, Jungsook; Lee, Kyeong; Nim Pae, Ae; Park, Ki Duk; Roh, Eun Joo.
Afiliação
  • Elkamhawy A; College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: a.elkamhawy@dongguk.edu.
  • Kim HJ; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
  • Elsherbeny MH; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, Seoul 02792, Republic of Korea; Pharmaceutical Chemistry Department, Faculty of Ph
  • Paik S; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
  • Park JH; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
  • Gotina L; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, Seoul 02792, Republic of Korea.
  • Abdellattif MH; Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Gouda NA; College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
  • Cho J; College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
  • Lee K; College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
  • Nim Pae A; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, Seoul 02792, Republic of Korea.
  • Park KD; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, Seoul 02792, Republic of Korea.
  • Roh EJ; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, Seoul 02792, Republic of Korea. Electronic address: r8636@kist.re.kr.
Bioorg Chem ; 116: 105352, 2021 11.
Article em En | MEDLINE | ID: mdl-34562673
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Descoberta de Drogas / Monoaminoxidase / Inibidores da Monoaminoxidase Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Descoberta de Drogas / Monoaminoxidase / Inibidores da Monoaminoxidase Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article