The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants.

Lin, Lisha; Li, Sujuan; Gao, Na; Wang, Weili; Zhang, Taocui; Yang, Lian; Yang, Xingzhi; Luo, Dan; Ji, Xu; Zhao, Jinhua

Lin, Lisha; Li, Sujuan; Gao, Na; Wang, Weili; Zhang, Taocui; Yang, Lian; Yang, Xingzhi; Luo, Dan; Ji, Xu; Zhao, Jinhua.

Afiliação

Lin L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Li S; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Gao N; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Wang W; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang T; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Yang L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Yang X; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Luo D; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Ji X; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhao J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

Mar Drugs ; 19(9)2021 Aug 27.

Article em En | MEDLINE | ID: mdl-34564149

Assuntos

Anticoagulantes/toxicidade; Glicosaminoglicanos/toxicidade; Animais; Anticoagulantes/química; Coagulação Sanguínea/efeitos dos fármacos; Pressão Sanguínea/efeitos dos fármacos; Fucose/química; Glicosaminoglicanos/química; Coração/efeitos dos fármacos; Coração/fisiologia; Frequência Cardíaca/efeitos dos fármacos; Pulmão/efeitos dos fármacos; Pulmão/patologia; Masculino; Ativação Plaquetária/efeitos dos fármacos; Embolia Pulmonar/induzido quimicamente; Embolia Pulmonar/patologia; Ratos Sprague-Dawley; Respiração/efeitos dos fármacos; Pepinos-do-Mar; Função Ventricular Esquerda/efeitos dos fármacos

Palavras-chave

anticoagulant; contact activation; fucosylated glycosaminoglycan; hypotension; platelet aggregation; pulmonary embolism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicosaminoglicanos / Anticoagulantes Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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