Anti-Virulence Strategy against the Honey Bee Pathogenic Bacterium <i>Paenibacillus larvae</i> via Small Molecule Inhibitors of the Bacterial Toxin Plx2A.

Ebeling, Julia; Pieper, Franziska; Göbel, Josefine; Knispel, Henriette; McCarthy, Michael; Goncalves, Monica; Turner, Madison; Merrill, Allan Rod; Genersch, Elke

Anti-Virulence Strategy against the Honey Bee Pathogenic Bacterium Paenibacillus larvae via Small Molecule Inhibitors of the Bacterial Toxin Plx2A.

Ebeling, Julia; Pieper, Franziska; Göbel, Josefine; Knispel, Henriette; McCarthy, Michael; Goncalves, Monica; Turner, Madison; Merrill, Allan Rod; Genersch, Elke.

Afiliação

Ebeling J; Department of Molecular Microbiology and Bee Diseases, Institute for Bee Research, 16540 Hohen Neuendorf, Germany.
Pieper F; Department of Molecular Microbiology and Bee Diseases, Institute for Bee Research, 16540 Hohen Neuendorf, Germany.
Göbel J; Department of Molecular Microbiology and Bee Diseases, Institute for Bee Research, 16540 Hohen Neuendorf, Germany.
Knispel H; Department of Molecular Microbiology and Bee Diseases, Institute for Bee Research, 16540 Hohen Neuendorf, Germany.
McCarthy M; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Goncalves M; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Turner M; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Merrill AR; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Genersch E; Department of Molecular Microbiology and Bee Diseases, Institute for Bee Research, 16540 Hohen Neuendorf, Germany.

Toxins (Basel) ; 13(9)2021 08 29.

Article em En | MEDLINE | ID: mdl-34564612

Assuntos

ADP Ribose Transferases/metabolismo; Proteínas de Bactérias/metabolismo; Toxinas Bacterianas/metabolismo; Abelhas/microbiologia; Paenibacillus larvae/patogenicidade; Fatores de Virulência/metabolismo; Virulência/efeitos dos fármacos; Animais; Interações Hospedeiro-Patógeno; Bibliotecas de Moléculas Pequenas

Palavras-chave

ADP-ribosylation; American Foulbrood; Paenibacillus larvae; anti-virulence strategy; bacterial toxin; small molecule inhibitor; virulence factor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Toxinas Bacterianas / Virulência / Abelhas / ADP Ribose Transferases / Fatores de Virulência / Paenibacillus larvae Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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