Morphine alkaloids: History, biology, and synthesis.

Wicks, Christopher; Hudlicky, Tomas; Rinner, Uwe

Wicks, Christopher; Hudlicky, Tomas; Rinner, Uwe.

Afiliação

Wicks C; Department of Chemistry and Centre for Biotechnology, Brock University, St. Catharines, ON, Canada.
Hudlicky T; Department of Chemistry and Centre for Biotechnology, Brock University, St. Catharines, ON, Canada.
Rinner U; IMC Fachhochschule Krems/IMC University of Applied Sciences Krems, Krems, Austria. Electronic address: uwe.rinner@fh-krems.ac.at.

Alkaloids Chem Biol ; 86: 145-342, 2021.

Article em En | MEDLINE | ID: mdl-34565506

ABSTRACT

ABSTRACT

This chapter provides a short overview of the history of morphine since it's isolation by Sertürner in 1805. The biosynthesis of the title alkaloid as well as all total and formal syntheses of morphine and codeine published after 1996 are discussed in detail. The last section of this chapter provides a detailed overview of medicinally relevant derivatives of the title alkaloid.

Assuntos

Alcaloides; Morfina; Biologia; Codeína

Palavras-chave

Alkaloids; Analgesia; Codeine; Medicinal derivatives; Morphine; Opioids; Opium; Total synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides / Morfina Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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