Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: A case of acute pancreatitis.
J Oncol Pharm Pract
; 28(2): 486-488, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-34569860
ABSTRACT
INTRODUCTION:
Acute pancreatitis associated with Pazopanib has been reported in the literature. Bitter Melon (Momordica Charantia) is traditionally used as a folk medicine in many regions. In this report, we describe a 65-year-old patient with a diagnosis of renal cell carcinoma, admitted to the hospital with symptoms of acute pancreatitis at the 8th year of pazopanib treatment. CASE REPORT The patient diagnosed with renal cell carcinoma was admitted to the hospital with the complaint of abdominal pain, nausea, and vomiting in the 8th year of Pazopanib treatment. It was noticed from the patient's history that he had received Bitter Melon extract for 4 days prior to the beginning of his complaints (100-150â ml/day). Levels of serum amylase and lipase were measured as 9163â U/L and 14,206â U/L, respectively. MANAGEMENT &OUTCOME:
Pazopanib drug was held. The patient was treated for acute pancreatitis. Pazopanib treatment was started again after the clinical condition of the patient had improved and levels of serum amylase and lipase had returned to normal levels. Levels of serum amylase and lipase did not increase again after re-administration of pazopanib treatment.DISCUSSION:
It is thought that Bitter Melon extract and pazopanib interaction might have led to acute pancreatitis. To the best of our knowledge, this case is the first to highlight the interaction of Bitter Melon extract with pazopanib. The Drug Interaction Probability Scale indicates that there is a probable association between bitter melon and acute pancreatitis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pancreatite
/
Pirimidinas
/
Sulfonamidas
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Extratos Vegetais
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Momordica charantia
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Interações Ervas-Drogas
/
Indazóis
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article