Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-&#954;B and MAPKs Pathways.

Tylek, Kinga; Trojan, Ewa; Leskiewicz, Monika; Regulska, Magdalena; Bryniarska, Natalia; Curzytek, Katarzyna; Lacivita, Enza; Leopoldo, Marcello; Basta-Kaim, Agnieszka

Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways.

Tylek, Kinga; Trojan, Ewa; Leskiewicz, Monika; Regulska, Magdalena; Bryniarska, Natalia; Curzytek, Katarzyna; Lacivita, Enza; Leopoldo, Marcello; Basta-Kaim, Agnieszka.

Afiliação

Tylek K; Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., 31-343 Kraków, Poland.
Trojan E; Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., 31-343 Kraków, Poland.
Leskiewicz M; Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., 31-343 Kraków, Poland.
Regulska M; Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., 31-343 Kraków, Poland.
Bryniarska N; Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., 31-343 Kraków, Poland.
Curzytek K; Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., 31-343 Kraków, Poland.
Lacivita E; Department of Pharmacy-Drug Sciences, University of Bari, Via Orabona 4, 70125 Bari, Italy.
Leopoldo M; Department of Pharmacy-Drug Sciences, University of Bari, Via Orabona 4, 70125 Bari, Italy.
Basta-Kaim A; Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., 31-343 Kraków, Poland.

Cells ; 10(9)2021 09 09.

Article em En | MEDLINE | ID: mdl-34572022

Assuntos

Anti-Inflamatórios/farmacologia; Lipopolissacarídeos/farmacologia; Microglia/efeitos dos fármacos; Proteínas Quinases Ativadas por Mitógeno/metabolismo; NF-kappa B/metabolismo; Receptores de Lipoxinas/agonistas; Transdução de Sinais/efeitos dos fármacos; Animais; Células Cultivadas; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Microglia/metabolismo; Fosforilação/efeitos dos fármacos; Ratos; Ratos Sprague-Dawley

Palavras-chave

MR-39; aspirin-triggered lipoxin A4; formyl peptide receptor 2; lipopolysaccharide; lipoxin A4; microglia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Lipopolissacarídeos / NF-kappa B / Microglia / Proteínas Quinases Ativadas por Mitógeno / Receptores de Lipoxinas / Anti-Inflamatórios Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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