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IL-17C and IL-17RE Promote Wound Closure in a Staphylococcus aureus-Based Murine Wound Infection Model.
Pätzold, Linda; Stark, Alexandra; Ritzmann, Felix; Meier, Carola; Tschernig, Thomas; Reichrath, Jörg; Bals, Robert; Bischoff, Markus; Beisswenger, Christoph.
Afiliação
  • Pätzold L; Institute for Medical Microbiology and Hygiene, Saarland University, 66421 Homburg, Germany.
  • Stark A; Department of Dermatology, Saarland University Hospital, 66421 Homburg, Germany.
  • Ritzmann F; Department of Internal Medicine V-Pulmonology, Allergology and Critical Care Medicine, Saarland University, 66421 Homburg, Germany.
  • Meier C; Institute of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany.
  • Tschernig T; Institute of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany.
  • Reichrath J; Department of Dermatology, Saarland University Hospital, 66421 Homburg, Germany.
  • Bals R; Department of Internal Medicine V-Pulmonology, Allergology and Critical Care Medicine, Saarland University, 66421 Homburg, Germany.
  • Bischoff M; Institute for Medical Microbiology and Hygiene, Saarland University, 66421 Homburg, Germany.
  • Beisswenger C; Department of Internal Medicine V-Pulmonology, Allergology and Critical Care Medicine, Saarland University, 66421 Homburg, Germany.
Microorganisms ; 9(9)2021 Aug 27.
Article em En | MEDLINE | ID: mdl-34576717
The epithelial cytokine interleukin-17C (IL-17C) mediates inflammation through the interleukin 17 receptor E (IL-17RE). Prior studies showed a detrimental role of IL-17C in the pathogenesis of immune-mediated skin diseases (e.g., psoriasis). Here, we examined the role of IL-17C/IL-17RE in wound closure in a Staphylococcus aureus wound infection model. We demonstrate that wound closure is significantly delayed in IL-17RE (Il-17re-/-)- and 17C (Il-17c-/-)-deficient mice. There was no significant difference between WT, Il-17re-/-, and Il-17c-/- mice in the absence of infection. Deficiency for IL-17RE and IL-17C did not significantly affect the elimination of bacteria. IL-17C expression was increased in the epidermis of human S. aureus-infected skin. Our results indicate that the IL-17C/IL-17RE axis contributes to the closure of infected wounds but does not contribute to the elimination of S. aureus.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article