The Mitochondria-Independent Cytotoxic Effect of Leflunomide on RPMI-8226 Multiple Myeloma Cell Line.

Adamczuk, Grzegorz; Humeniuk, Ewelina; Iwan, Magdalena; Natorska-Chomicka, Dorota; Adamczuk, Kamila; Korga-Plewko, Agnieszka

Adamczuk, Grzegorz; Humeniuk, Ewelina; Iwan, Magdalena; Natorska-Chomicka, Dorota; Adamczuk, Kamila; Korga-Plewko, Agnieszka.

Afiliação

Adamczuk G; Independent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.
Humeniuk E; Independent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.
Iwan M; Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.
Natorska-Chomicka D; Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.
Adamczuk K; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Medical University of Lublin, 20-093 Lublin, Poland.
Korga-Plewko A; Independent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.

Molecules ; 26(18)2021 Sep 17.

Article em En | MEDLINE | ID: mdl-34577124

Assuntos

Leflunomida; Mieloma Múltiplo; Antineoplásicos; Apoptose/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Crotonatos; Inibidores Enzimáticos/farmacologia; Humanos; Hidroxibutiratos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Nitrilas; Toluidinas

Palavras-chave

dehydrogenase dihydroorotate; leflunomide; mitochondria; multiple myeloma; protein tyrosine kinases; teriflunomide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leflunomida / Mieloma Múltiplo Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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