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Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
Li, Tao; Yu, Diankun; Oak, Hayeon C; Zhu, Beika; Wang, Li; Jiang, Xueqiao; Molday, Robert S; Kriegstein, Arnold; Piao, Xianhua.
Afiliação
  • Li T; Weill Institute for Neuroscience, University of California, San Francisco (UCSF), San Francisco, CA, USA.
  • Yu D; Newborn Brain Research Institute, University of California, San Francisco (UCSF), San Francisco, CA, USA.
  • Oak HC; Weill Institute for Neuroscience, University of California, San Francisco (UCSF), San Francisco, CA, USA.
  • Zhu B; Newborn Brain Research Institute, University of California, San Francisco (UCSF), San Francisco, CA, USA.
  • Wang L; Weill Institute for Neuroscience, University of California, San Francisco (UCSF), San Francisco, CA, USA.
  • Jiang X; Newborn Brain Research Institute, University of California, San Francisco (UCSF), San Francisco, CA, USA.
  • Molday RS; Weill Institute for Neuroscience, University of California, San Francisco (UCSF), San Francisco, CA, USA.
  • Kriegstein A; Newborn Brain Research Institute, University of California, San Francisco (UCSF), San Francisco, CA, USA.
  • Piao X; Weill Institute for Neuroscience, University of California, San Francisco (UCSF), San Francisco, CA, USA.
EMBO J ; 40(21): e107915, 2021 11 02.
Article em En | MEDLINE | ID: mdl-34585770
Synaptic refinement is a critical physiological process that removes excess synapses to establish and maintain functional neuronal circuits. Recent studies have shown that focal exposure of phosphatidylserine (PS) on synapses acts as an "eat me" signal to mediate synaptic pruning. However, the molecular mechanism underlying PS externalization at synapses remains elusive. Here, we find that murine CDC50A, a chaperone of phospholipid flippases, localizes to synapses, and that its expression depends on neuronal activity. Cdc50a knockdown leads to phosphatidylserine exposure at synapses and subsequent erroneous synapse removal by microglia partly via the GPR56 pathway. Taken together, our data support that CDC50A safeguards synapse maintenance by regulating focal phosphatidylserine exposure at synapses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilserinas / Sinapses / Microglia / Receptores Acoplados a Proteínas G / Proteínas de Membrana / Neurônios Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilserinas / Sinapses / Microglia / Receptores Acoplados a Proteínas G / Proteínas de Membrana / Neurônios Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article