3-MC, 3-methylcholanthrene; 5-ASA, 5-aminosalicylic acid; AIM2, absent in melanoma 2; ATG5, autophagy-related protein 5; ATG7, autophagy-related protein 7; ATP, adenosine triphosphate; Autophagy; BMDMs, bone marrow-derived macrophages; CETSA, cellular thermal shift assay; CHX, cycloheximide; ChIP, chromatin immunoprecipitation; Colitis; DAI, disease activity index; DAMPs, damage-associated molecular patterns; DMSO, dimethyl sulfoxide; DSS, dextran sulfate sodium; DTT, dithiothreitol; ECL, enhanced chemiluminescent; EDTA, ethylenediaminetetraacetic acid; ELISA, enzyme-linked immunosorbent assay; EZH2; EZH2, enhancer of zeste homolog 2; FBS, fetal bovine serum; H&E, hematoxylin and eosin; LPS, lipopolysaccharide; Lonicerin; M-CSF, macrophage colony stimulating factor; MDP, muramyldipeptide; MPO, myeloperoxidase; MSU, monosodium urate crystals; NLRP3 inflammasome; NLRP3, nucleotide-binding domain-like receptors family pyrin domain containing 3; PAMPs, pathogen-associated molecular patterns; PMA, phorbol myristate acetate; PMSF, phenylmethanesulfonyl fluoride; PRC2, polycomb repressive complex 2; RMSD, root mean-square deviation; RMSF, root mean-square fluctuation; SIP, solvent-induced protein precipitation; TEM, transmission electron microscopy; UC, ulcerative colitis