Development of 2'-aminospiro [pyrano[3,2-c]quinoline]-3'-carbonitrile derivatives as non-ATP competitive Src kinase inhibitors that suppress breast cancer cell migration and proliferation.

Ramadan, Mohamed; A M M Elshaier, Yaseen; Aly, Ashraf A; Abdel-Aziz, Mohamed; Fathy, Hazem M; Brown, Alan B; Pridgen, Jacey R; Dalby, Kevin N; Kaoud, Tamer S

Ramadan, Mohamed; A M M Elshaier, Yaseen; Aly, Ashraf A; Abdel-Aziz, Mohamed; Fathy, Hazem M; Brown, Alan B; Pridgen, Jacey R; Dalby, Kevin N; Kaoud, Tamer S.

Afiliação

Ramadan M; Department of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Egypt.
A M M Elshaier Y; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufia 32958, Egypt.
Aly AA; Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt. Electronic address: ashraf.shehata@mu.edu.eg.
Abdel-Aziz M; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Fathy HM; Department of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Egypt.
Brown AB; Chemistry Department, Florida Institute of Technology, Melbourne, FL 32901, USA.
Pridgen JR; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, the University of Texas at Austin, Austin, TX 78712, USA.
Dalby KN; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, the University of Texas at Austin, Austin, TX 78712, USA.
Kaoud TS; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, the University of Texas at Austin, Austin, TX 78712, USA. Electronic address: tkaood1@utexas.edu.

Bioorg Chem ; 116: 105344, 2021 11.

Article em En | MEDLINE | ID: mdl-34598088

Assuntos

Antineoplásicos/farmacologia; Neoplasias da Mama/tratamento farmacológico; Desenvolvimento de Medicamentos; Inibidores de Proteínas Quinases/farmacologia; Piranos/farmacologia; Quinolinas/farmacologia; Quinases da Família src/antagonistas & inibidores; Antineoplásicos/síntese química; Antineoplásicos/química; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Células HEK293; Humanos; Estrutura Molecular; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Piranos/síntese química; Piranos/química; Quinolinas/síntese química; Quinolinas/química; Relação Estrutura-Atividade; Quinases da Família src/metabolismo

Palavras-chave

2-(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)-malononitrile; 2-(2,7-dibromo-9H-fluoren-9-ylidene)malononitrile; 2-(2-oxoacenaphthylen-1(2H)-ylidene)-malononitrile; 4-hydroxyquinolone; Breast cancer cell migration; Breast cancer cell proliferation; Pyrano[3,2-c]quinolone; Spirocyclic scaffolds; Src kinase inhibitor; non-ATP competitive inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piranos / Quinolinas / Neoplasias da Mama / Quinases da Família src / Inibidores de Proteínas Quinases / Desenvolvimento de Medicamentos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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