CDKL5 kinase controls transcription-coupled responses to DNA damage.

Khanam, Taran; Muñoz, Ivan; Weiland, Florian; Carroll, Thomas; Morgan, Michael; Borsos, Barbara N; Pantazi, Vasiliki; Slean, Meghan; Novak, Miroslav; Toth, Rachel; Appleton, Paul; Pankotai, Tibor; Zhou, Houjiang; Rouse, John

Khanam, Taran; Muñoz, Ivan; Weiland, Florian; Carroll, Thomas; Morgan, Michael; Borsos, Barbara N; Pantazi, Vasiliki; Slean, Meghan; Novak, Miroslav; Toth, Rachel; Appleton, Paul; Pankotai, Tibor; Zhou, Houjiang; Rouse, John.

Afiliação

Khanam T; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Muñoz I; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Weiland F; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Carroll T; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Morgan M; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Borsos BN; Albert Szent-Györgyi Medical School, Institute of Pathology, University of Szeged, Szeged, Hungary.
Pantazi V; Albert Szent-Györgyi Medical School, Institute of Pathology, University of Szeged, Szeged, Hungary.
Slean M; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Novak M; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Toth R; MRC Reagents and Services, School of Life Sciences, University of Dundee, Dundee, UK.
Appleton P; Dundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee, UK.
Pankotai T; Albert Szent-Györgyi Medical School, Institute of Pathology, University of Szeged, Szeged, Hungary.
Zhou H; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Rouse J; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.

EMBO J ; 40(23): e108271, 2021 12 01.

Article em En | MEDLINE | ID: mdl-34605059

Assuntos

Quebras de DNA de Cadeia Dupla; Dano ao DNA; Elonguina/metabolismo; Neurônios/patologia; Fosfoproteínas/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Ativação Transcricional; Elonguina/genética; Síndromes Epilépticas/genética; Síndromes Epilépticas/metabolismo; Síndromes Epilépticas/patologia; Humanos; Mutação; Neurônios/metabolismo; Fosfoproteínas/genética; Fosforilação; Poli Adenosina Difosfato Ribose/metabolismo; Proteínas Serina-Treonina Quinases/genética; Espasmos Infantis/genética; Espasmos Infantis/metabolismo; Espasmos Infantis/patologia

Palavras-chave

CDKL5 disorder; DNA damage response; kinase; poly(ADP-ribose); transcriptional regulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Dano ao DNA / Ativação Transcricional / Proteínas Serina-Treonina Quinases / Quebras de DNA de Cadeia Dupla / Elonguina / Neurônios Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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