Elevated serum creatine kinase levels due to osimertinib: A case report and review of the literature.
J Oncol Pharm Pract
; 28(2): 489-494, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-34605320
ABSTRACT
INTRODUCTION:
Osimertinib is a tyrosine kinase inhibitor that targets the epidermal growth factor receptor. Elevated serum creatine kinase level is an uncommon adverse event associated with osimertinib treatment for lung cancer. CASE REPORT We report a previously healthy 56-year-old woman who developed elevated serum creatine kinase levels during osimertinib monotherapy for epidermal growth factor receptor mutation-positive lung adenocarcinoma. MANAGEMENT &OUTCOME:
During treatment, she experienced leg cramps and her serum creatine kinase levels increased, peaking at 989 U/l. Further investigation revealed no evidence of cardiotoxicity or myositis; thus, osimertinib-induced myopathy was assumed to be the cause of her elevated serum creatine kinase levels. We successfully managed both lung cancer and osimertinib-induced myopathy using 1-week pauses of osimertinib therapy without dose reduction.DISCUSSION:
Short-term suspension of osimertinib without dose reduction may be a reasonable option for osimertinib-induced myopathy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
Limite:
Female
/
Humans
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Middle aged
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article