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Chromatin dynamics in human brain development and disease.
Valencia, Alfredo M; Pașca, Sergiu P.
Afiliação
  • Valencia AM; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
  • Pașca SP; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: spasca@stanford.edu.
Trends Cell Biol ; 32(2): 98-101, 2022 02.
Article em En | MEDLINE | ID: mdl-34610892
Chromatin-related genes are frequently mutated in neurodevelopmental disorders; yet, the mechanisms by which these perturbations disrupt brain assembly and function are not understood. Here, we describe how recent advances in transcriptional and chromatin profiling in combination with cellular models are beginning to inform our understanding of neurodevelopment and chromatinopathies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatina / Transtornos do Neurodesenvolvimento Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatina / Transtornos do Neurodesenvolvimento Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article