A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA.

Sanchez-Contreras, Monica; Sweetwyne, Mariya T; Kohrn, Brendan F; Tsantilas, Kristine A; Hipp, Michael J; Schmidt, Elizabeth K; Fredrickson, Jeanne; Whitson, Jeremy A; Campbell, Matthew D; Rabinovitch, Peter S; Marcinek, David J; Kennedy, Scott R

Sanchez-Contreras, Monica; Sweetwyne, Mariya T; Kohrn, Brendan F; Tsantilas, Kristine A; Hipp, Michael J; Schmidt, Elizabeth K; Fredrickson, Jeanne; Whitson, Jeremy A; Campbell, Matthew D; Rabinovitch, Peter S; Marcinek, David J; Kennedy, Scott R.

Afiliação

Sanchez-Contreras M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Sweetwyne MT; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Kohrn BF; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Tsantilas KA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Hipp MJ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Schmidt EK; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Fredrickson J; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Whitson JA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Campbell MD; Department of Radiology, University of Washington, Seattle, WA 98195, USA.
Rabinovitch PS; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Marcinek DJ; Department of Radiology, University of Washington, Seattle, WA 98195, USA.
Kennedy SR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.

Nucleic Acids Res ; 49(19): 11103-11118, 2021 11 08.

Article em En | MEDLINE | ID: mdl-34614167

Assuntos

Envelhecimento/genética; Replicação do DNA; DNA Mitocondrial/genética; Genoma Mitocondrial; Mutação em Linhagem Germinativa; Mitocôndrias/genética; Acúmulo de Mutações; Envelhecimento/metabolismo; Animais; Mapeamento Cromossômico; DNA Polimerase gama/deficiência; DNA Polimerase gama/genética; DNA Mitocondrial/metabolismo; Especiação Genética; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Mitocôndrias/metabolismo; Taxa de Mutação; Polimorfismo de Nucleotídeo Único

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / DNA Mitocondrial / Mutação em Linhagem Germinativa / Replicação do DNA / Genoma Mitocondrial / Acúmulo de Mutações / Mitocôndrias Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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