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Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates.
Huang, Zhouyang; King, A Paden; Lovett, James; Lai, Barry; Woods, Joshua J; Harris, Hugh H; Wilson, Justin J.
Afiliação
  • Huang Z; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. jjw275@cornell.edu.
  • King AP; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. jjw275@cornell.edu.
  • Lovett J; Department of Chemistry, The University of Adelaide, South Australia 5005, Australia.
  • Lai B; Advanced Photon Source, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA.
  • Woods JJ; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. jjw275@cornell.edu.
  • Harris HH; Robert F. Smith School for Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.
  • Wilson JJ; Department of Chemistry, The University of Adelaide, South Australia 5005, Australia.
Chem Commun (Camb) ; 57(85): 11189-11192, 2021 Oct 26.
Article em En | MEDLINE | ID: mdl-34622255
ABSTRACT
The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy showed that Pt and Re colocalize in cells whether they had been irradiated or not. This work demonstrates the potential of photoactivated multilimetallic agents for combating cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Platina / Rênio / Complexos de Coordenação / Antineoplásicos Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Platina / Rênio / Complexos de Coordenação / Antineoplásicos Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article