The Trypanosome-Derived Metabolite Indole-3-Pyruvate Inhibits Prostaglandin Production in Macrophages by Targeting COX2.

Diskin, Ciana; Corcoran, Sarah E; Tyrrell, Victoria J; McGettrick, Anne F; Zaslona, Zbigniew; O'Donnell, Valerie B; Nolan, Derek P; O'Neill, Luke A J

Diskin, Ciana; Corcoran, Sarah E; Tyrrell, Victoria J; McGettrick, Anne F; Zaslona, Zbigniew; O'Donnell, Valerie B; Nolan, Derek P; O'Neill, Luke A J.

Afiliação

Diskin C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; and.
Corcoran SE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; and.
Tyrrell VJ; Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom.
McGettrick AF; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; and.
Zaslona Z; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; and.
O'Donnell VB; Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Nolan DP; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; and.
O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; and laoneill@tcd.ie.

J Immunol ; 207(10): 2551-2560, 2021 11 15.

Article em En | MEDLINE | ID: mdl-34635586

Assuntos

Ciclo-Oxigenase 2/metabolismo; Indóis/metabolismo; Macrófagos/imunologia; Prostaglandinas/metabolismo; Tripanossomíase Africana/imunologia; Animais; Humanos; Evasão da Resposta Imune/imunologia; Indóis/imunologia; Macrófagos/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Prostaglandinas/imunologia; Trypanosoma brucei brucei/imunologia; Trypanosoma brucei brucei/metabolismo; Tripanossomíase Africana/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tripanossomíase Africana / Prostaglandinas / Ciclo-Oxigenase 2 / Indóis / Macrófagos Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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