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The MEK 1/2 inhibitor PD98059 exhibits synergistic anti-endometrial cancer activity with paclitaxel in vitro and enhanced tissue distribution in vivo when formulated into PAMAM-coated PLGA-PEG nanoparticles.
Wiwatchaitawee, Kanawat; Mekkawy, Aml I; Quarterman, Juliana C; Naguib, Youssef W; Ebeid, Kareem; Geary, Sean M; Salem, Aliasger K.
Afiliação
  • Wiwatchaitawee K; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, USA.
  • Mekkawy AI; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, USA.
  • Quarterman JC; Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag, 82524, Egypt.
  • Naguib YW; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, USA.
  • Ebeid K; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, USA.
  • Geary SM; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
  • Salem AK; Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Manufacturing, Deraya University, New Minia City, 61768, Minia, Egypt.
Drug Deliv Transl Res ; 12(7): 1684-1696, 2022 07.
Article em En | MEDLINE | ID: mdl-34635984
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Nanopartículas Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Nanopartículas Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article