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Disparate effects of ankle-brachial index on mortality in the 'very old' and 'younger old' populations-the PolSenior survey.
Królczyk, Jaroslaw; Skalska, Anna; Piotrowicz, Karolina; Mossakowska, Malgorzata; Grodzicki, Tomasz; Gasowski, Jerzy.
Afiliação
  • Królczyk J; Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.
  • Skalska A; University Hospital in Krakow, Krakow, Poland.
  • Piotrowicz K; Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.
  • Mossakowska M; University Hospital in Krakow, Krakow, Poland.
  • Grodzicki T; Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.
  • Gasowski J; University Hospital in Krakow, Krakow, Poland.
Heart Vessels ; 37(4): 665-672, 2022 Apr.
Article em En | MEDLINE | ID: mdl-34643792
To assess the relationship between ankle-brachial index (ABI) and up to 10-year mortality in older individuals below and above the age of 80 years. In a multicenter survey of health status in the community dwelling subjects aged 55-59 and 65 + years in Poland, we assessed baseline medical history including risk-factors. We measured ABI, and serum creatinine, cholesterol, NT-proBNP, and interleukin-6 (IL-6) concentrations. We assessed mortality based on public registry. Between 2009 and 2019, 27.3% of 561 participants < 80 years, and 79.4% of 291 participants ≥ 80 years, died (p < 0.001); 67.8, 41.5, and 40.3% in the ABI groups < 0.9, 0.9-1.4, and > 1.4, respectively (p < 0.01). In the unadjusted Cox models, ABI was associated with mortality in the entire group, and < 80 years. In the entire group, analysis adjusted for age and sex showed mortality risk increased by 11% per year, and 50% with male sex. Mortality decreased by 37% per 1 unit ABI increase. In the group of people ≥ 80 years, only age was significantly associated with mortality (p < 0.001). In stepwise regression ABI < 0.9, male sex, active smoking, and NT-proBNP level were associated with risk of death < 80 years. In the ≥ 80 years old, mortality risk was associated with older age, and higher levels of IL-6, but not ABI. The ABI < 0.9 is associated with higher mortality in older people, but not among the oldest-old. In the oldest age group, age is the strongest predictor of death. In this age group, inflammageing is of importance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colesterol / Índice Tornozelo-Braço Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colesterol / Índice Tornozelo-Braço Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article