Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration.

Kong, Stephanie M; Costa, Daniel F; Jagielska, Anna; Van Vliet, Krystyn J; Hammond, Paula T

Kong, Stephanie M; Costa, Daniel F; Jagielska, Anna; Van Vliet, Krystyn J; Hammond, Paula T.

Afiliação

Kong SM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
Costa DF; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Jagielska A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
Van Vliet KJ; Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139.
Hammond PT; Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139.

Proc Natl Acad Sci U S A ; 118(42)2021 10 19.

Article em En | MEDLINE | ID: mdl-34649991

Assuntos

Nanopartículas/química; Neoplasias/metabolismo; Linhagem Celular Tumoral; Sistemas de Liberação de Medicamentos; Meia-Vida; Humanos; Lipossomos; Polímeros/química; Distribuição Tecidual

Palavras-chave

cancer; drug delivery; liposomes; modulus; targeting

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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