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Autoimmune glial fibrillary acidic protein astrocytopathy resembling isolated central nervous system lymphomatoid granulomatosis.
Kimura, Akio; Kato, Shinei; Takekoshi, Akira; Yoshikura, Nobuaki; Yanagida, Narufumi; Kitaguchi, Hiroshi; Akiyama, Daisuke; Shimizu, Hiroshi; Kakita, Akiyoshi; Shimohata, Takayoshi.
Afiliação
  • Kimura A; Department of Neurology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Gifu, Japan. Electronic address: kimura1@gifu-u.ac.jp.
  • Kato S; Department of Neurology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Gifu, Japan. Electronic address: shinei.kato@gmail.com.
  • Takekoshi A; Department of Neurology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Gifu, Japan. Electronic address: takekosi@gifu-u.ac.jp.
  • Yoshikura N; Department of Neurology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Gifu, Japan. Electronic address: ny1113@gifu-u.ac.jp.
  • Yanagida N; Department of Neurology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, Japan. Electronic address: yanasoi@kuhp.kyoto-u.ac.jp.
  • Kitaguchi H; Department of Neurology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, Japan. Electronic address: hiroshi.kitaguchi21@gmail.com.
  • Akiyama D; Department of Hematology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, Japan. Electronic address: da17006@kchnet.or.jp.
  • Shimizu H; Department of Pathology, Brain Research Institute, Niigata University, 1-757 Asahimachidori, Chuo-ku Niigata, Niigata, Japan. Electronic address: hshimizu@bri.niigata-u.ac.jp.
  • Kakita A; Department of Pathology, Brain Research Institute, Niigata University, 1-757 Asahimachidori, Chuo-ku Niigata, Niigata, Japan. Electronic address: kakita@bri.niigata-u.ac.jp.
  • Shimohata T; Department of Neurology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Gifu, Japan. Electronic address: shimohata@gmail.com.
J Neuroimmunol ; 361: 577748, 2021 12 15.
Article em En | MEDLINE | ID: mdl-34653948
We report two patients with meningoencephalomyelitis without evidence of extra central nervous system (CNS) involvement. Brain MRI showed linear perivascular radial gadolinium enhancement patterns and spinal cord MRI showed longitudinal extensive T2-hyperintensity lesions. Pathological findings from brain biopsies were angiocentric T-cell predominant lymphoid infiltrates that lacked Epstein-Barr virus-positive atypical B cells. The patients were initially suspected to have isolated CNS-lymphomatoid granulomatosis (LYG). Thereafter, glial fibrillary acidic protein (GFAP)-immunoglobulin G were detected in their cerebrospinal fluid. This finding suggested autoimmune GFAP astrocytopathy. We speculate there is a link between isolated CNS-LYG and autoimmune GFAP astrocytopathy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrócitos / Doenças Autoimunes do Sistema Nervoso / Proteína Glial Fibrilar Ácida / Granulomatose Linfomatoide Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies Limite: Aged / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrócitos / Doenças Autoimunes do Sistema Nervoso / Proteína Glial Fibrilar Ácida / Granulomatose Linfomatoide Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies Limite: Aged / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article