Clinically Significant CUX1 Mutations Are Frequently Subclonal and Common in Myeloid Disorders With a High Number of Co-mutated Genes and Dysplastic Features.

Dermawan, Josephine K; Wensel, Christine; Visconte, Valeria; Maciejewski, Jaroslaw P; Cook, James R; Bosler, David S

Dermawan, Josephine K; Wensel, Christine; Visconte, Valeria; Maciejewski, Jaroslaw P; Cook, James R; Bosler, David S.

Afiliação

Dermawan JK; Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Wensel C; Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Visconte V; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Maciejewski JP; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Cook JR; Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Bosler DS; Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

Am J Clin Pathol ; 157(4): 586-594, 2022 04 01.

Article em En | MEDLINE | ID: mdl-34661647

Assuntos

Síndromes Mielodisplásicas; Transtornos Mieloproliferativos; Idoso; Proteínas de Homeodomínio; Humanos; Pessoa de Meia-Idade; Mutação; Síndromes Mielodisplásicas/genética; Prognóstico; Proteínas Repressoras/genética; Fatores de Transcrição/genética

Palavras-chave

CUX1; Clonality; Co-mutations; Myeloid neoplasms; Variant classification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Transtornos Mieloproliferativos Tipo de estudo: Prognostic_studies Limite: Aged / Humans / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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