Your browser doesn't support javascript.
loading
Diversity in the supramolecular interactions of 5,6-dichloro-2-(trifluoromethyl)-1H-benzimidazole with modified cyclodextrins: Implications for physicochemical properties and antiparasitic activity.
Rojas-Aguirre, Yareli; Castillo, Ivan; Hernández, David J; Nogueda-Torres, Benjamín; Márquez-Navarro, Adrián; Villalobos, Juan C; Sánchez-Bartéz, Francisco; Sánchez-Torres, Luvia; Gracia-Mora, Isabel; Castillo, Rafael; Hernández-Luis, Francisco.
Afiliação
  • Rojas-Aguirre Y; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, México, DF 04360, Mexico.
  • Castillo I; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México, DF 04360, Mexico.
  • Hernández DJ; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México, DF 04360, Mexico.
  • Nogueda-Torres B; Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, DF 11340, Mexico.
  • Márquez-Navarro A; Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, DF 11340, Mexico.
  • Villalobos JC; Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, DF 11340, Mexico.
  • Sánchez-Bartéz F; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, México, DF 04360, Mexico.
  • Sánchez-Torres L; Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, DF 11340, Mexico.
  • Gracia-Mora I; Facultad de Química, Departamento de Química Inorgánica y Nuclear, Universidad Nacional Autónoma de México, DF 04360, Mexico.
  • Castillo R; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, México, DF 04360, Mexico.
  • Hernández-Luis F; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, México, DF 04360, Mexico. Electronic address: franher@unam.mx.
Carbohydr Polym ; 87(1): 471-479, 2012 Jan 04.
Article em En | MEDLINE | ID: mdl-34662992
The molecular interactions of 5,6-dichloro-2-(trifluoromethyl)-1H-benzimidazole (G2), an antiprotozoa with poor aqueous solubility, with 2-hydroxypropyl-α-cyclodextrin (HPαCD), methyl-ß-cyclodextrin (MßCD) and 2-hydroxypropyl-ß-cyclodextrin (HPßCD) were examined. The aqueous solubility enhancement by cyclodextrins (CDs) was evidenced in phase-solubility diagrams, and the stoichiometry of G2/CD systems was determined by Job's plots. Two-dimensional NMR spectroscopic data revealed that a different mode of interaction took place between G2 and CDs in solution. With HPαCD, a non-inclusion complex was generated. In the case of MßCD, a typical host-guest system was obtained and with HPßCD a partial inclusion complex through the narrow side of the macrocycle was formed. ESI-mass spectrometric data confirmed the stoichiometry and mode of interaction of these systems in solution. Solid-state characterization (scanning calorimetry and powder X-ray diffraction) supported the inclusion complex formation. The leishmanicidal activity, trypanocidal activity and non-toxic profile of G2/MßCD showed the advantages of using this inclusion complex to promote the biological assays extension of G2.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2012 Tipo de documento: Article