Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine.
Biochem Soc Trans
; 49(5): 2189-2198, 2021 11 01.
Article
em En
| MEDLINE
| ID: mdl-34665229
ABSTRACT
Inflammation is a critical component of cardiovascular disease (CVD), encompassing coronary artery disease (CAD), cerebrovascular events and heart failure and is the leading cause of mortality worldwide. In recent years, metabolism has been placed centrally in the governance of the immune response. Termed immunometabolism, immune cells adapt cellular metabolic pathways to meet demands of activation and thus function. This rewiring influences not only the bioenergetics of the cell but altered metabolites act as signalling molecules to regulate cellular response. In this review, we focus on the TCA cycle derivative, itaconate, as one such metabolite with promising immunomodulatory and therapeutic potential in inflammatory cardiovascular disease.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Succinatos
/
Doenças Cardiovasculares
/
Mediadores da Inflamação
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article