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Olfactory impairment in mild cognitive impairment with Lewy bodies and Alzheimer's disease.
Thomas, Alan J; Hamilton, Calum A; Barker, Sally; Durcan, Rory; Lawley, Sarah; Barnett, Nicola; Firbank, Michael; Roberts, Gemma; Allan, Louise M; O'Brien, John; Taylor, John-Paul; Donaghy, Paul C.
Afiliação
  • Thomas AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, U.K.
  • Hamilton CA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, U.K.
  • Barker S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, U.K.
  • Durcan R; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, U.K.
  • Lawley S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, U.K.
  • Barnett N; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, U.K.
  • Firbank M; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, U.K.
  • Roberts G; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, U.K.
  • Allan LM; University of Exeter Medical School, University of Exeter, Exeter, U.K.
  • O'Brien J; Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, U.K.
  • Taylor JP; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, U.K.
  • Donaghy PC; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, U.K.
Int Psychogeriatr ; 34(6): 585-592, 2022 06.
Article em En | MEDLINE | ID: mdl-34666863
ABSTRACT

OBJECTIVES:

Impaired olfaction may be a biomarker for early Lewy body disease, but its value in mild cognitive impairment with Lewy bodies (MCI-LB) is unknown. We compared olfaction in MCI-LB with MCI due to Alzheimer's disease (MCI-AD) and healthy older adults. We hypothesized that olfactory function would be worse in probable MCI-LB than in both MCI-AD and healthy comparison subjects (HC).

DESIGN:

Cross-sectional study assessing olfaction using Sniffin' Sticks 16 (SS-16) in MCI-LB, MCI-AD, and HC with longitudinal follow-up. Differences were adjusted for age, and receiver operating characteristic (ROC) curves were used for discriminating MCI-LB from MCI-AD and HC.

SETTING:

Participants were recruited from Memory Services in the North East of England.

PARTICIPANTS:

Thirty-eight probable MCI-LB, 33 MCI-AD, 19 possible MCI-LB, and 32HC. MEASUREMENTS Olfaction was assessed using SS-16 and a questionnaire.

RESULTS:

Participants with probable MCI-LB had worse olfaction than both MCI-AD (age-adjusted mean difference (B) = 2.05, 95% CI 0.62-3.49, p = 0.005) and HC (B = 3.96, 95% CI 2.51-5.40, p < 0.001). The previously identified cutoff score for the SS-16 of ≤ 10 had 84% sensitivity for probable MCI-LB (95% CI 69-94%), but 30% specificity versus MCI-AD. ROC analysis found a lower cutoff of ≤ 7 was better (63% sensitivity for MCI-LB, with 73% specificity vs MCI-AD and 97% vs HC). Asking about olfactory impairments was not useful in identifying them.

CONCLUSIONS:

MCI-LB had worse olfaction than MCI-AD and normal aging. A lower cutoff score of ≤ 7 is required when using SS-16 in such patients. Olfactory testing may have value in identifying early LB disease in memory services.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença por Corpos de Lewy / Doença de Alzheimer / Disfunção Cognitiva / Transtornos do Olfato Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença por Corpos de Lewy / Doença de Alzheimer / Disfunção Cognitiva / Transtornos do Olfato Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article