Novel Anti-Tubulin Compounds from <i>Trigonella foenum-graecum</i> Seeds; Insights into In-vitro and Molecular Docking Studies.

Alghamdi, Sahar Saleh; Suliman, Rasha Saad; Alsaeed, Amjad Sulaiman; Almutairi, Khlood Khaled; Aljammaz, Norah Abdulaziz; Altolayyan, Abdulelah; Ali, Rizwan; Alhallaj, Alshaimaa

Novel Anti-Tubulin Compounds from Trigonella foenum-graecum Seeds; Insights into In-vitro and Molecular Docking Studies.

Alghamdi, Sahar Saleh; Suliman, Rasha Saad; Alsaeed, Amjad Sulaiman; Almutairi, Khlood Khaled; Aljammaz, Norah Abdulaziz; Altolayyan, Abdulelah; Ali, Rizwan; Alhallaj, Alshaimaa.

Afiliação

Alghamdi SS; College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Suliman RS; Medical Research Core Facility and Platforms, King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.
Alsaeed AS; College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Almutairi KK; Medical Research Core Facility and Platforms, King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.
Aljammaz NA; College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Altolayyan A; College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Ali R; College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Alhallaj A; Medical Research Core Facility and Platforms, King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Drug Des Devel Ther ; 15: 4195-4211, 2021.

Article em En | MEDLINE | ID: mdl-34675483

Assuntos

Antineoplásicos Fitogênicos/farmacologia; Neoplasias/tratamento farmacológico; Extratos Vegetais/farmacologia; Moduladores de Tubulina/farmacologia; Antineoplásicos Fitogênicos/administração & dosagem; Antineoplásicos Fitogênicos/química; Linhagem Celular Tumoral; Cromatografia Líquida de Alta Pressão; Cromatografia Líquida; Humanos; Concentração Inibidora 50; Espectrometria de Massas; Simulação de Acoplamento Molecular; Neoplasias/patologia; Extratos Vegetais/administração & dosagem; Extratos Vegetais/química; Trigonella/química; Tubulina (Proteína)/efeitos dos fármacos; Tubulina (Proteína)/metabolismo; Moduladores de Tubulina/administração & dosagem; Moduladores de Tubulina/química

Palavras-chave

QTOF-LC/Ms metabolites; computational pharmacokinetics ADME; fenugreek Trigonella foenum-graecum; tubulin inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Moduladores de Tubulina / Neoplasias / Antineoplásicos Fitogênicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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