Model-Informed Precision Dosing during Infliximab Induction Therapy Reduces Variability in Exposure and Endoscopic Improvement between Patients with Ulcerative Colitis.

Faelens, Ruben; Wang, Zhigang; Bouillon, Thomas; Declerck, Paul; Ferrante, Marc; Vermeire, Séverine; Dreesen, Erwin

Faelens, Ruben; Wang, Zhigang; Bouillon, Thomas; Declerck, Paul; Ferrante, Marc; Vermeire, Séverine; Dreesen, Erwin.

Afiliação

Faelens R; Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Wang Z; Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Bouillon T; Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Declerck P; Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Ferrante M; Department of Gastroenterology and Hepatology, University Hospitals Leuven, 3000 Leuven, Belgium.
Vermeire S; Department of Chronic Diseases and Metabolism, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Dreesen E; Department of Gastroenterology and Hepatology, University Hospitals Leuven, 3000 Leuven, Belgium.

Pharmaceutics ; 13(10)2021 Oct 06.

Article em En | MEDLINE | ID: mdl-34683916

Palavras-chave

endoscopy; inflammatory bowel disease; infliximab; model-informed precision dosing; monoclonal antibody; population pharmacokinetics-pharmacodynamics; simulations; therapeutic drug monitoring; ulcerative colitis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article