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Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles.
Aksenov, Alexander V; Aksenov, Nicolai A; Aleksandrova, Elena V; Aksenov, Dmitrii A; Grishin, Igor Yu; Sorokina, Elena A; Wenger, Allison; Rubin, Michael.
Afiliação
  • Aksenov AV; Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
  • Aksenov NA; Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
  • Aleksandrova EV; Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
  • Aksenov DA; Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
  • Grishin IY; Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
  • Sorokina EA; Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya St., 117198 Moscow, Russia.
  • Wenger A; Department of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USA.
  • Rubin M; Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
Molecules ; 26(20)2021 Oct 11.
Article em En | MEDLINE | ID: mdl-34684712
ABSTRACT
The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1H-indole byproducts. Herein, we offer a workaround this problem that allows for effective transformation of the unwanted byproducts into acetonitrile target molecules.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article