Ceramide accumulation induces mitophagy and impairs ß-oxidation in PINK1 deficiency.

Vos, Melissa; Dulovic-Mahlow, Marija; Mandik, Frida; Frese, Lisa; Kanana, Yuliia; Haissatou Diaw, Sokhna; Depperschmidt, Julia; Böhm, Claudia; Rohr, Jonas; Lohnau, Thora; König, Inke R; Klein, Christine

Vos, Melissa; Dulovic-Mahlow, Marija; Mandik, Frida; Frese, Lisa; Kanana, Yuliia; Haissatou Diaw, Sokhna; Depperschmidt, Julia; Böhm, Claudia; Rohr, Jonas; Lohnau, Thora; König, Inke R; Klein, Christine.

Afiliação

Vos M; Institute of Neurogenetics, University of Luebeck, 23562 Luebeck, Germany; melissa.vos@neuro.uni-luebeck.de christine.klein@neuro.uni-luebeck.de.
Dulovic-Mahlow M; Institute of Neurogenetics, University of Luebeck, 23562 Luebeck, Germany.
Mandik F; Institute of Neurogenetics, University of Luebeck, 23562 Luebeck, Germany.
Frese L; Institute of Neurogenetics, University of Luebeck, 23562 Luebeck, Germany.
Kanana Y; Institute of Neurogenetics, University of Luebeck, 23562 Luebeck, Germany.
Haissatou Diaw S; Institute of Neurogenetics, University of Luebeck, 23562 Luebeck, Germany.
Depperschmidt J; Institute of Neurogenetics, University of Luebeck, 23562 Luebeck, Germany.
Böhm C; Institute of Neurogenetics, University of Luebeck, 23562 Luebeck, Germany.
Rohr J; Institute of Neurogenetics, University of Luebeck, 23562 Luebeck, Germany.
Lohnau T; Institute of Neurogenetics, University of Luebeck, 23562 Luebeck, Germany.
König IR; Institut für Medizinische Biometrie und Statistik, University of Luebeck, 23562 Luebeck, Germany.
Klein C; Institute of Neurogenetics, University of Luebeck, 23562 Luebeck, Germany; melissa.vos@neuro.uni-luebeck.de christine.klein@neuro.uni-luebeck.de.

Proc Natl Acad Sci U S A ; 118(43)2021 10 26.

Article em En | MEDLINE | ID: mdl-34686591

Assuntos

Ceramidas/metabolismo; Mitofagia/fisiologia; Doença de Parkinson/fisiopatologia; Proteínas Quinases/deficiência; Animais; Autofagia; Proteínas de Drosophila/deficiência; Proteínas de Drosophila/genética; Proteínas de Drosophila/metabolismo; Drosophila melanogaster/genética; Drosophila melanogaster/metabolismo; Fibroblastos/metabolismo; Fibroblastos/patologia; Humanos; Metabolismo dos Lipídeos; Camundongos; Camundongos Knockout; Mitofagia/genética; Oxirredução; Oxirredutases/antagonistas & inibidores; Oxirredutases/genética; Doença de Parkinson/genética; Doença de Parkinson/patologia; Proteínas Quinases/genética; Proteínas Quinases/metabolismo; Proteínas Serina-Treonina Quinases/deficiência; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo

Palavras-chave

PINK1; Parkinson's disease; ceramide; mitochondria; ß-oxidation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Quinases / Ceramidas / Mitofagia Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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