Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway.

Zhang, Xuan-Xuan; Ji, Ya-Li; Zhu, Li-Ping; Wang, Zi-Han; Fang, Chang-Qian; Jiang, Cui-Hua; Pan, Ke; Zhang, Jian; Yin, Zhi-Qi

Zhang, Xuan-Xuan; Ji, Ya-Li; Zhu, Li-Ping; Wang, Zi-Han; Fang, Chang-Qian; Jiang, Cui-Hua; Pan, Ke; Zhang, Jian; Yin, Zhi-Qi.

Afiliação

Zhang XX; Department of TCMs Pharmaceuticals & Department of Natural Medicinal Chemistry, School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, 211198, PR China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine,
Ji YL; Department of TCMs Pharmaceuticals & Department of Natural Medicinal Chemistry, School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, 211198, PR China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine,
Zhu LP; Department of TCMs Pharmaceuticals & Department of Natural Medicinal Chemistry, School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, 211198, PR China.
Wang ZH; Department of TCMs Pharmaceuticals & Department of Natural Medicinal Chemistry, School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, 211198, PR China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine,
Fang CQ; Department of Endocrinology, Nanjing Lishui District Hospital of Traditional Chinese Medicine, Nanjing, 211200, PR China.
Jiang CH; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, PR China.
Pan K; Department of TCMs Pharmaceuticals & Department of Natural Medicinal Chemistry, School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, 211198, PR China.
Zhang J; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, PR China. Electronic address: zhangjian@jsatcm.com.
Yin ZQ; Department of TCMs Pharmaceuticals & Department of Natural Medicinal Chemistry, School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: cpu-yzq@cpu.edu.cn.

J Ethnopharmacol ; 284: 114772, 2022 Feb 10.

Article em En | MEDLINE | ID: mdl-34688801

Assuntos

Adenilato Quinase/metabolismo; Retinopatia Diabética/tratamento farmacológico; Heme Oxigenase (Desciclizante)/metabolismo; Juglandaceae/química; Serina-Treonina Quinases TOR/metabolismo; Triterpenos/uso terapêutico; Adenilato Quinase/genética; Animais; Autofagia/efeitos dos fármacos; Diabetes Mellitus Experimental; Retinopatia Diabética/metabolismo; Regulação da Expressão Gênica/efeitos dos fármacos; Heme Oxigenase (Desciclizante)/genética; Masculino; Estrutura Molecular; Fitoterapia; Extratos Vegetais; Distribuição Aleatória; Ratos; Ratos Sprague-Dawley; Triterpenos/química

Palavras-chave

AMPK/mTOR/HO-1; Arjunolic acid; Autophagy; Cyclocarya paliurus; Diabetic retinopathy

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Adenilato Quinase / Juglandaceae / Retinopatia Diabética / Serina-Treonina Quinases TOR / Heme Oxigenase (Desciclizante) Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google