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The Role of Long Non-coding RNA, Nuclear Enriched Abundant Transcript 1 (NEAT1) in Cancer and Other Pathologies.
Zhang, Miao; Guo, Jianmin; Liu, Lifei; Huang, Mei; Li, Yuexuan; Bennett, Samuel; Xu, JiaKe; Zou, Jun.
Afiliação
  • Zhang M; School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, China.
  • Guo J; School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, China.
  • Liu L; School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, China.
  • Huang M; School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, China.
  • Li Y; School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, China.
  • Bennett S; School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
  • Xu J; School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
  • Zou J; School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, China. junzou@sus.edu.cn.
Biochem Genet ; 60(3): 843-867, 2022 Jun.
Article em En | MEDLINE | ID: mdl-34689290
ABSTRACT
Nuclear enriched abundant transcript 1 (NEAT1), consisting of two kinds of lncRNAs of 3.7 kB NEAT1-1 and 23 kB NEAT1-2, can be highly expressed in organs and tissues such as the ovary, prostate, colon, and pancreas, and is involved in paraspeckle formation and mRNA editing and gene expression. Therefore, NEAT1 is a potential biomarker for the treatment of a variety of diseases, which may be caused by two factors (isoforms of NEAT1 and NEAT1 sponging miRNA as ceRNA). However, there is still much confusion about the mechanism and downstream effector between the abnormal expression of NEAT1 and various diseases. This review summarizes recent research progress on NEAT1 in cancer and other pathologies and provides a more reliable theoretical basis for the treatment of related diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / RNA Longo não Codificante / Neoplasias Limite: Female / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / RNA Longo não Codificante / Neoplasias Limite: Female / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article