Glabridin synergy with norfloxacin induces ROS in multidrug resistant Staphylococcus aureus.
J Gen Appl Microbiol
; 67(6): 269-272, 2021 Dec 31.
Article
em En
| MEDLINE
| ID: mdl-34690227
ABSTRACT
Glabridin (Glb), a polyphenolic flavonoid inhibits the growth of MDRSA (Multidrug resistant S. aureus) 4627 by inducing ROS. Glb in combination with Norfloxacin (Nor) synergistically induced oxidative stress. Increased ROS/RNS levels, in particular, affected macromolecules' (DNA, lipid, protein) integrity and distorted cell morphology. We found correlation between drug-effects and up-/down-regulation of oxidative stress-related as well as MDR genes. These findings could considerably potentiate the dosing routine of Nor in combination with Glb, which holds a promising prospective as a antibacterial agent against S. aureus.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Norfloxacino
/
Staphylococcus aureus Resistente à Meticilina
Tipo de estudo:
Observational_studies
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article