Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes.

Kinnebrew, Maia; Luchetti, Giovanni; Sircar, Ria; Frigui, Sara; Viti, Lucrezia Vittoria; Naito, Tomoki; Beckert, Francis; Saheki, Yasunori; Siebold, Christian; Radhakrishnan, Arun; Rohatgi, Rajat

Kinnebrew, Maia; Luchetti, Giovanni; Sircar, Ria; Frigui, Sara; Viti, Lucrezia Vittoria; Naito, Tomoki; Beckert, Francis; Saheki, Yasunori; Siebold, Christian; Radhakrishnan, Arun; Rohatgi, Rajat.

Afiliação

Kinnebrew M; Department of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, United States.
Luchetti G; Department of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, United States.
Sircar R; Department of Physiological Chemistry, Genentech, South San Francisco, United States.
Frigui S; Department of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, United States.
Viti LV; Department of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, United States.
Naito T; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Beckert F; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Saheki Y; Department of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, United States.
Siebold C; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Radhakrishnan A; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Rohatgi R; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, United States.

Elife ; 102021 10 26.

Article em En | MEDLINE | ID: mdl-34698632

Assuntos

Membrana Celular/metabolismo; Colesterol/metabolismo; Receptor Patched-1/genética; Receptor Smoothened/genética; Animais; Escherichia coli; Humanos; Camundongos; Receptor Patched-1/metabolismo; Receptor Smoothened/metabolismo

Palavras-chave

cell biology; cholesterol; cholesterol accessibility; developmental biology; hedgehog signaling; ion gradient; membrane biology; membrane protein; mouse; patched; primary cilia; smoothened; transporter

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membrana Celular / Colesterol / Receptor Patched-1 / Receptor Smoothened Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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