Related expression of TRKA and P75 receptors and the changing copy number of <i>MYC</i>-oncogenes determine the sensitivity of brain tumor cells to the treatment of the nerve growth factor in combination with cisplatin and temozolomide.

Chernov, Alexandr N; Alaverdian, Diana A; Glotov, Oleg S; Talabaev, Michael V; Urazov, Stanislav P; Shcherbak, Sergei G; Renieri, Alessandra; Frullanti, Elisa; Shamova, Olga

Related expression of TRKA and P75 receptors and the changing copy number of MYC-oncogenes determine the sensitivity of brain tumor cells to the treatment of the nerve growth factor in combination with cisplatin and temozolomide.

Chernov, Alexandr N; Alaverdian, Diana A; Glotov, Oleg S; Talabaev, Michael V; Urazov, Stanislav P; Shcherbak, Sergei G; Renieri, Alessandra; Frullanti, Elisa; Shamova, Olga.

Afiliação

Chernov AN; Department of Clinics and Genetics Investigations, Saint Petersburg City Hospital No40 of Resort District, Saint Petersburg, Russian Federation.
Alaverdian DA; Laboratory of Design and Synthesis of Biologically Active Peptides, Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Saint-Petersburg, Russian Federation.
Glotov OS; Medical Genetics, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Talabaev MV; Department of Clinics and Genetics Investigations, Saint Petersburg City Hospital No40 of Resort District, Saint Petersburg, Russian Federation.
Urazov SP; Department of Pediatric Neurosurgery, Republican Center for Neurology and Neurosurgery, Minsk, The Republic of Belarus.
Shcherbak SG; Department of Clinics and Genetics Investigations, Saint Petersburg City Hospital No40 of Resort District, Saint Petersburg, Russian Federation.
Renieri A; Department of Clinics and Genetics Investigations, Saint Petersburg City Hospital No40 of Resort District, Saint Petersburg, Russian Federation.
Frullanti E; Medical Genetics, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Shamova O; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

Drug Metab Pers Ther ; 35(4)2020 09 04.

Article em En | MEDLINE | ID: mdl-34704697

Assuntos

Neoplasias Encefálicas; Cisplatino; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/genética; Cisplatino/farmacologia; Variações do Número de Cópias de DNA; Humanos; Hibridização in Situ Fluorescente; Fator de Crescimento Neural/genética; Fator de Crescimento Neural/farmacologia; Oncogenes; Receptor de Fator de Crescimento Neural/fisiologia; Receptor trkA/genética; Receptor trkA/metabolismo; Temozolomida/farmacologia

Palavras-chave

MYCC-; MYCN-oncogenes; Trka; chemotherapy; nerve growth factor (NGF); p75 receptors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Cisplatino Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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