Amino Acid Homeostasis in Mammalian Cells with a Focus on Amino Acid Transport.
J Nutr
; 152(1): 16-28, 2022 01 11.
Article
em En
| MEDLINE
| ID: mdl-34718668
ABSTRACT
Amino acid homeostasis is maintained by import, export, oxidation, and synthesis of nonessential amino acids, and by the synthesis and breakdown of protein. These processes work in conjunction with regulatory elements that sense amino acids or their metabolites. During and after nutrient intake, amino acid homeostasis is dominated by autoregulatory processes such as transport and oxidation of excess amino acids. Amino acid deprivation triggers processes such as autophagy and the execution of broader transcriptional programs to maintain plasma amino acid concentrations. Amino acid transport plays a crucial role in the absorption of amino acids in the intestine, the distribution of amino acids across cells and organs, the recycling of amino acids in the kidney, and the recycling of amino acids after protein breakdown.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Aminoácidos
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article