Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase &#945;-primase.

Kilkenny, Mairi L; Veale, Charlotte E; Guppy, Amir; Hardwick, Steven W; Chirgadze, Dimitri Y; Rzechorzek, Neil J; Maman, Joseph D; Pellegrini, Luca

Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase α-primase.

Kilkenny, Mairi L; Veale, Charlotte E; Guppy, Amir; Hardwick, Steven W; Chirgadze, Dimitri Y; Rzechorzek, Neil J; Maman, Joseph D; Pellegrini, Luca.

Afiliação

Kilkenny ML; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Veale CE; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Guppy A; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Hardwick SW; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Chirgadze DY; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Rzechorzek NJ; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Maman JD; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Pellegrini L; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.

Protein Sci ; 31(2): 333-344, 2022 02.

Article em En | MEDLINE | ID: mdl-34719824

Assuntos

COVID-19; SARS-CoV-2; Proteínas não Estruturais Virais; Microscopia Crioeletrônica; DNA Polimerase I; DNA Primase; Humanos; Proteômica; Proteínas não Estruturais Virais/genética; Fatores de Virulência

Palavras-chave

DNA polymerase α-primase; SARS-CoV-2; cryo-EM; nsp1; protein-protein interaction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas não Estruturais Virais / SARS-CoV-2 / COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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