Chirality from D-guanosine to L-guanosine shapes a stable gel for three-dimensional cell culture.

Du, Yuqi; Liu, Tiannan; Tang, Fan; Jin, Xin; Zhao, Hang; Liu, Jiang; Zeng, Xin; Chen, Qianming

Du, Yuqi; Liu, Tiannan; Tang, Fan; Jin, Xin; Zhao, Hang; Liu, Jiang; Zeng, Xin; Chen, Qianming.

Afiliação

Du Y; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China. liujiang@scu.edu.cn.
Liu T; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China. liujiang@scu.edu.cn.
Tang F; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China. liujiang@scu.edu.cn.
Jin X; Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing 400016, P. R. China.
Zhao H; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China. liujiang@scu.edu.cn.
Liu J; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China. liujiang@scu.edu.cn.
Zeng X; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China. liujiang@scu.edu.cn.
Chen Q; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China. liujiang@scu.edu.cn.

Chem Commun (Camb) ; 57(96): 12936-12939, 2021 Dec 03.

Article em En | MEDLINE | ID: mdl-34734933

ABSTRACT

ABSTRACT

It is proved that L-guanosine (L-G) as an enantiomer of D-guanosine (D-G) forms more stable gels than D-G, suggesting that alteration of chirality may be a new strategy for improving the lifetime stability of supramolecular hydrogels. Experiments for three-dimensional cell culture reveal that the L-G gel is a candidate for the extracellular matrix.

Assuntos

Técnicas de Cultura de Células; Guanosina/química; Células Cultivadas; Matriz Extracelular/química; Géis/química; Humanos; Conformação de Ácido Nucleico; Estereoisomerismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas de Cultura de Células / Guanosina Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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