t(14;18) Translocations in Dioxin-Exposed Workers.
J Occup Environ Med
; 64(4): 331-339, 2022 04 01.
Article
em En
| MEDLINE
| ID: mdl-34740219
ABSTRACT
OBJECTIVE:
To determine if occupational exposure to dioxins is associated with an increased frequency of t(14;18) translocations.METHODS:
A cross-sectional analysis of serum dioxin levels and t(14;18) frequencies in peripheral blood mononuclear cells in 218 former chemical plant workers and 150 population controls.RESULTS:
The workers had significantly higher geometric mean serum levels of 2,3,7,8-TCDD (26.2 vs 2.5 ppt) and TEQ (73.8 vs 17.7 ppt) than controls. There were no significant differences in the prevalence or frequency of t(14;18) translocations in the workers compared to controls. Among former workers with current or past chloracne who were t(14;18) positive, the frequency of translocations significantly increased with quartiles of 2,3,7,8-TCDD and TEQ.CONCLUSION:
Chloracne appears to modulate the association between dioxin exposure and increased frequency of t(14;18) translocations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exposição Ocupacional
/
Dioxinas
/
Cloracne
/
Dibenzodioxinas Policloradas
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article